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The microfluidic structure integrated two channels (single inlet-single outlet and triple inlet-single outlet) with simple mixers, which allow even fluid or gas delivery to a cavity that accommodates the 5 × 5 mm Au-AAO sensing platform (Figure 2).
The substrate binding site is illustrated in Figure 4. Several large hydrophobic residues, Trp-54, Trp-92, Met-270, and Tyr-294, produce a cavity that accommodates ethanol as the best substrate.
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The C-terminal active site of TryS is a triangular-shaped cavity that accommodates each of the three substrates (ATP, GSH and spermidine).
A comparison of the ChsE4-ChsE5 substrate-binding sito thoseofe of known mammalian ACADs reveals an enlarged binding cavity that accommodates steroid substrates and highlights novel prospects for designing inhibitors against the committed β-oxidation step in the first cycle of cholesterol side chain degradation by Mtb.
Cyclodextrins are a family of cyclic oligosaccharides that create a 3-dimensional toroid structure, providing a cavity that can accommodate small hydrophobic molecules, such as cholesterol or steroids.
The recent structure of Thermus complex I shows a cavity that can easily accommodate at least one isoprenoid unit in the hydrophobic tail of Q, even if a Q molecule was not visible in the X-ray images.
The RNA was shown to exist tightly bound in a cavity that provides a hydrophobic space to accommodate the bases of the RNA.
A cavity that had to be drilled cost $151.
In particular, the bowl-shaped cavity of a molecular receptor known as resorcin[4]arene has been elaborated, using hydrogen bonds, for the construction of open and closed cavities that accommodate single and multiple guest species.
Our 3D reconstruction of SWR1 does not show a central cavity that could accommodate a nucleosome, as has been observed for the RSC complex (Chaban et al., 2008; Leschziner et al., 2007).
Similar to previous peptide-bound structures, WDR5 adopts a doughnut-shaped WD40-repeat fold with a deep central cavity that normally accommodates an arginine side chain of interacting peptides [ 21– 237 38] 38].
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