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The term "mutant gene," while clearly identifiable as a "cause of variation" by a biologist, was too rare to be incorporated into the scoring models (Table 4).
All that we could show was that the 'size of the unit' was not a cause of variation between dialysis units.
However these genes themselves may either be not polymorphic, or the power of the pQTL analysis was not sufficient to detect them, or trait associated expression of these genes is rather an effect than a cause of variation.
Taken together, these results suggest that variation in the expression of Munc18b or other limiting components of the MC exocytic machinery could alter the release of preformed inflammatory mediators by this cell and be a cause of variation in resistance to infection or susceptibility to inflammatory diseases [ 29, 44].
This proposal introduces an implementation strategy distinguished by several innovations: (1) a systematic process for clinical guideline translation; (2) a peer-to-peer consulting intervention that integrates relevant theory with empirical research on organizational change [ 1, 14, 15]; and (3) an explicit focus on process as a cause of variation in outcomes [ 29].
If a trait A is significantly associated with a genetic marker M, variation in M must be a cause of variation in A (denoted by M → A) since the randomization of marker alleles during meiosis precedes their effect on trait A. Since the orientation of the edge between M and A is unambiguous, M is referred to as a causal anchor of A [ 15].
Similar(54)
Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation.
Perturbations of 5mC have been implicated as a cause of phenotypic variation among plants regenerated through in vitro culture systems.
This was suggested as a cause of rate variation in non-coding DNA in the Lentibulareaceae [ 9].
This residual donor cell gene expression within hiPSCs may be a cause of the variations in teratoma formation thereafter [20].
29 However, a systematic review showed little evidence of different beliefs in clinical indications as a cause of regional variations in use of coronary angiography, upper gastrointestinal endoscopy and carotid endarterectomy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com