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Therefore, reduced PG levels in CD patients in remission observed here may make them susceptible to relapse, although elevated levels during active disease could be a cause of tissue damage.
In agreement with our conclusions, increased levels of OPN have been implicated in many pathophysiological disorders and as a cause of tissue fibrosis; and in the mouse model of muscular dystrophy (MDX mice) where inflammation becomes exacerbated with time, OPN knockout improves tissue health [ 20, 23- 25, 41].
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A ferret isolate (10-8545) displaned an rpoB sequence with 100% similarity to that of M. celatum; this species has been documented as a cause of soft tissue infection in ferrets [ 18].
Progressive damage to articular cartilage is a hallmark of OA, and a principal cause of tissue break-down is the destruction rather than formation of the cartilage extracellular matrix by chondrocytes.
In response, Bakker disagreed that the sepsis syndrome must always be the result of infection as a nonmicrobiological cause of tissue injury could precipitate an identical syndrome of organ dysfunction.
Oxidative stress is considered a major cause of tissue injury from irradiation.
However, excessive activation of neutrophils is a direct cause of tissue damage and organ failure in sepsis [39, 58].
Oxidative stress is a major cause of tissue damage and inflammation [ 23].
This makes senescent cells a potential cause of tissue functional decline in aging.
A prominent cause of tissue damage is excessive leucocyte accumulation as in the cases of arthritis or periodontal disease [ 2].
S. aureus, in addition to causing blood stream infections, is a significant cause of tissue infections such as pneumonia and osteomyelitis [ 5].
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