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Furthermore, increased expression of Bcl-2 family proteins is a cause of acquired resistance to chemotherapeutic agents.
Because of this, and the high frequency of MMR-defective melanoma cell line (1 out of 11), down-regulation or impaired MMR might be considered (together with up-regulation of MGMT) a cause of acquired resistance to TMZ and other methylating drugs.
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Neurocysticercosis is a major cause of acquired epilepsy in the developing world (1 – 3 ) and an emerging public health issue in the United States because of emigration from and travel to areas in Latin America, Asia, and Africa where the disease is endemic (4 – 6 ).
A major cause of acquired primary hypothyroidism is chronic autoimmune thyroiditis (inflammation of the thyroid).
Accommodative esotropia is a common cause of acquired esotropia.
Stroke constitutes a major cause of acquired disability in adults and the second most frequent cause of mortality in developed nations [2].
There is a need for additional information on non-fatal pediatric pedestrian injuries and the role of traumatic brain injury (TBI), a leading cause of acquired disability.
Background and Aim: Rheumatic fever is still a common cause of acquired heart disease in children and young adult in many developing countries.
APS is a common cause of acquired vascular thrombosis [ 1] and recurrent miscarriage [ 2].
Stroke is the second leading cause of death and a major cause of acquired disability worldwide [ 1].
Soluble factors as cytokines and growth factors secreted by stromal cells are a major cause of acquired resistance [ 13].
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