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The associations reported in this paper do not prove or imply a causative link; and paradoxically agents that might cause gastrointestinal haemorrhage were not associated with greater degrees of iron deficiency.
Altogether, Down syndrome may be considered as a cause of both asthma and acute leukaemia and drawing a causative link from asthma to acute leukaemia in this setting seems a raw conclusion.
More importantly, these animal studies have been supported by concurrent clinical data showing that blood-brain barrier disruption (BBBD) causes seizures in human subjects [4] and that BBBD has a causative link with post-traumatic epilepsy [3].
Of course, the absence of evidence of a causative link is not evidence of its absence.
Although a large body of evidence supports a causative link between oxidative stress and neurodegeneration, the mechanisms are still elusive.
A causative link between enhanced glutamate release and facilitation of CSD, induced by brief pulses of high K+, has been reported in mouse models of CSD [48 51].
Using an in vitro model of CSD [59], a causative link between enhanced glutamate release and CSD facilitation has been shown.
This case demonstrates that keratitis may lead to keratoconus-like corneal changes and supports the hypothesis of a causative link between recurrent inflammatory process and the development of keratoconus.
The studies suggest that the viruses one of which also widely circulates in animals in Vietnam could be involved in brain inflammation and paraplegia, but further studies are needed to confirm a causative link.
Accurate and precise 40Ar/39Ar dates on initial rhyolitic ignimbrite eruptions suggest that silicic flood volcanism in Afro-Arabia post-dates the Oligocene Oi2 global cooling event, ruling out a causative link between these explosive silicic eruptions (with individual volumes ≥200 km3) and climatic cooling which produced the first major expansion of the Antarctic ice sheets.
Whether there's a causative link between those two variables is an open question within the research literature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com