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The inhibition of the miRNAs, particularly miR-26b, unequivocally demonstrates a causative effect by HU on the induction of HbF through miRNA-mediated mechanisms.
Fatty acid composition and carbohydrate levels differ in the E. coli strains examined in these studies, however these nutrient differences did not appear to have a causative effect on fat storage levels in worms.
However, the association demonstrated in this study, together with published data, strongly suggest such a causative effect.
It can be questioned if a SNP in the intron region has a causative effect on phenotypic traits.
Recently, we provided genetic basis to support the conclusion that mitochondrial dysfunction may have a causative effect in motor neuron degeneration.
Although we are unable to determine whether hypobilirubinemia has a causative effect, these findings suggest that hypobilirubinemia combined with diabetes might be associated with advanced diabetic nephropathy.
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The cross-sectional design precludes us to establish whether a high TG-to-HDL-C ratio has any causative effect on cardiac and liver abnormalities as well as on their progression in adulthood.
Our previous genome linkage study identifying chromosomal regions 20 associated with malaria that overlap with those previously shown to be linked to asthma/atopy suggests that there may be a shared genetic basis to these pathologies rather than any causative effect of one on the other.
It is possible that tumour IFP may be more a marker of treatment response than have a direct causative effect on metastatic spread.
Assuming the genetic associations we identified are real, they may either be due to a direct causative effect of the SNPs tested, or because these tSNPs are in linkage disequilibrium and serve as markers for the real determinant of a disease.
However, a direct causative effect of cellular senescence on ageing has never been shown.
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