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The observed disappearance of group A cases from the whole of Niger is likely related to both a natural dynamic of meningitis epidemics in the belt and massive vaccination with polysaccharide A/C vaccines in previous years [ 6, 13].
To identify molecular mechanisms and signalling pathways specifically deregulated in luminal B tumours, we compared the genomic profiles of 41 luminal B and 59 luminal A cases from this panel (Supplementary Table 1) by using high density aCGH.
Using reported influenza A cases from both hospitals between August 2001 and August 2011, we prospectively applied the ALERT algorithm to compute historical performance metrics for a range of possible thresholds.
In the case of Sircoulomb et al. recurrent high-level amplifications (8p12, 8q22, 11q13, 17q24, 20q13) were observed first in 41 luminal B and 59 luminal A cases from a series of 266 and then in 1172 breast cancers from 11 different published datasets which included 561 luminal tumours (Luminal A and B, Sircoulomb et al, 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com