The CsA-hCYP-A binding to calcineurin inhibits the phosphatase activity of calcineurin that results in a cascade of activities leading to the inactivation of T-cells [ 7].
Under normal conditions, DCs are present in most tissues in a relatively immature state, but with inflammation, irritation or danger signals from foreign antigens or environment, iDCs undergo rapid changes and initiate a cascade of activities to defend the body system.
Here we hypothesized that synthetic biomarkers could be tailored to survey intravascular sites for acute thrombosis, the activation of a cascade of protease activity that orchestrates the formation of obstructive blood clots within vessels.
But excess glutamate triggers a cascade of worrisome activity.
"When I see you smiling, my mirror neurons for smiling fire up, too, initiating a cascade of neural activity that evokes the feeling we typically associate with a smile".
The process of apoptosis involves a cascade of proteolytic activity, much of it carried out by caspases.
The degradation of pectin is thought to be the first step in a cascade of CWDE activity [ 70, 157, 158].
The reflex cough test (RCT), using nebulized tartaric acid solution, provides an effective stimulus to the receptors in the supraglottic mucosa, and, like a reflex hammer or percussor, triggers a cascade of neurological activity in both craniospinal nerves and the central nervous system.
The urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) are essential for proteolysis in many solid tumours, the main mechanism being the activation of plasminogen-dependent proteolysis and a cascade of protolytic activities, leading to extracellular matrix degradation, invasion, intravasation, and metastasis establishment (Jo et al, 2003; Dass et al, 2008).
When E. coli is placed under stress, a cascade of gene activities is initiated, involving several global regulators such as MarA and MicF, which result in the down-regulation of porins [11], [27], [34].
