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In a career-defining performance, Roy Scheider starred as the driven, womanizing, self-destructive director-choreographer.
The writers followed up with "Legally Blonde," in which Reese Witherspoon gave a career-defining performance.
And among the many scenery-gobblers here, Daniel Stewart, as Malvolio, Olivia's censorious, self-righteous steward, gives a career-defining performance.
Mike Leigh Mike Leigh's sensational new film features a career-defining performance from Imelda Staunton: a Bafta shoo-in and, if there's any justice, a British Oscar success story in 2005.
There he was, hanging out with Jimi Hendrix and Mick Jagger, taking Eric Clapton to see Syd Barrett's Pink Floyd (alas on a night their errant frontman decided to play the same note over and over again for hours), and delivering a career-defining performance at Woodstock in 1969 despite being spiked with LSD.
A career-defining performance by J.K Simmons.
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The film featured Edward G. Robinson in a career defining performance as gangster Rico Bandello.
This line is mumbled by actor Heath Ledger, in the midst of an arresting and career-defining performance as Ennis, in which his anguished taciturnity seems both consonant with some of the finest performers in cinematic westerns - Henry Fonda, John Wayne - and entirely plausible - according to a more realistic code of the cinematic west, which Lee has announced as one of his own ambitions.
Griffith was Oscar-nominated and won a Golden Globe for her career-defining performance but it's her Cinderella-like makeover – going from leather blousons, brassy jewellery and candyfloss mullet to sensible bob, slinky frocks and Armani power suits – that sticks in the memory.
Fox's biggest star, Theda Bara, misbehaved in several hit films, including her career-defining performance as a man-eater in A Fool There Was, mouthing the killer line: "Kiss me, my fool".
She became an international sensation after her career-defining performance in the title role of "Lucia di Lammermoor" at Covent Garden — its first presentation there since 1925 — which opened on Feb. 17, 1959.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com