The phrase "a carcinogenic mutation" is correct and usable in written English.
It can be used in discussions related to genetics, cancer research, or toxicology to describe a mutation that has the potential to cause cancer.
Example: "The study revealed that exposure to certain chemicals can lead to a carcinogenic mutation in the DNA of living organisms."
Alternatives: "cancer-causing mutation" or "tumor-inducing mutation".
None of these respective studies described a significant influence of the hepatic tumour load on liver functional parameters or the behaviour of mice compared to their littermates that did not carry the carcinogenic mutation [ 195, 196 , 198]
If a cell fails to repair this DNA damage, it could accumulate carcinogenic mutations, causing a malignant transformation.
Given the impressive replication fidelity of normal cells [estimated mutation rate of between 10−9 and 10−10 per base pair per division (Salk et al. 2010)], it has been argued that an elevated mutation rate is required to acquire this large number of carcinogenic mutations within a reasonable time (Loeb 2001).
Interestingly, whereas two clearly carcinogenic mutations, R683W and R601L, showed a clear reduction in the XPD-CAK interaction (down to about 44%and33%3%, respectively, of the normal interaction capacity), the third one, R683Q, displayed an elevated interaction capacity with CAK.
Absorption of ultraviolet light by DNA is known to lead to carcinogenic mutations, but the processes between photon absorption and the photochemical reactions are poorly understood.
Moreover, carcinogenic mutations may not be identical for each individual.
This may increase the likelihood for DNA damage and carcinogenic mutations [ 5].
Cell proliferation is needed to fix and clonally expand carcinogenic mutations resulting from chemically-induced DNA damage.
To our knowledge, most of the putative carcinogenic mutations we found have not been implicated in tumorigenesis previously.
Fiber endoscopic imaging of tissue types requiring much higher powers to obtain useable diagnostic images may indicate limited feasibility due to the danger of potentially carcinogenic mutations occurring.
