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The probeset was categorized as a candidate alternative exon.
Here we present evidence for a new ADAR2 splice variant that extends the open reading frame of ADAR2 by 49 amino acids through the utilization of an exon located 18 kilobases upstream of the previously annotated first coding exon and driven by a candidate alternative promoter.
If a read did not align to the genome or a known splice, but aligned to an alternative splice (thus skipping one or more exons in known isoforms, or else forming an inter-known-isoform splice) it was considered as a candidate alternative splicing event.
In 66% (24/35) of cases, there was a candidate alternative in frame boundary (GT or AG) within 9 nts of the JEC21 boundary position (and one case of an alternative boundary 12 nt away), and many of these alternative boundaries had extended consensus sequences (i.e., a 5' GT/CRAG or 3' YAG; Table 1).
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In the next step, the 'Feasible Alternatives' key is pressed to obtain a list of candidate alternatives satisfying all the set criteria values.
Samvedi et al. (2012) integrated fuzzy AHP and grey relational analysis (GRA) approaches for selection of a machine tool from a given set of candidate alternatives.
In addition, Cr was evaluated as a candidate of an alternative Cu-diffusion barrier material.
Due to relatively high AmNLG3 expression throughout development (discussed below), AmNLG3 was chosen as a candidate to investigate alternative splicing.
LiCoPO4 (LCP) is a promising candidate as alternative cathode for high-voltage lithium-ion batteries.
Sapkota, P. & Kim, H. Zinc-air fuel cell, a potential candidate for alternative energy.
Radio-frequency (RF) energy harvesting is a promising candidate for alternative power source that can reduce the dependencies on batteries.
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