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The phrase "a calamitous combination" is correct and usable in written English.
It can be used to describe a situation where two or more elements come together in a way that leads to disaster or significant negative consequences.
Example: "The merger of the two companies proved to be a calamitous combination, resulting in financial losses and a tarnished reputation."
Alternatives: "a disastrous mix" or "a catastrophic pairing".
Exact(3)
Belafonte's performance of "Losing Hand" — a song written by Charles Calhoun for Ray Charles, who had a hit with it, in 1953 — is, for me, a calamitous combination of the sly and the wounded.
O'Neill did what he could to help Carter without betraying his own fundamental beliefs, but the relatively modest accomplishments of the Carter administration were not enough to offset a calamitous combination of political disasters, including double-digit inflation and interest rates, increased unemployment and the inability to orchestrate a return of the hostages from Iran.
The trials and tribulations he suffered under the high ball were of Old Testament proportions – more than once, a calamitous combination of poor positioning and terminal Teflonitis dropped England in the mire – and it was only when he switched places with Mark Cueto that the overpowering whiff of a series of accidents waiting to happen disappeared on the breeze.
Similar(57)
It is a calamitous desire.
Of course, that followed a calamitous decline.
"It's a calamitous mess.
If so, it was a calamitous mistake.
Aid workers feared a calamitous battle for the city.
It was a calamitous miscalculation for Syria and for Turkey.
Baghdad's hospitals were in a calamitous state.
England finished on a high after a calamitous start.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com