Sentence examples for a bystander response from inspiring English sources

In this study, we aimed to assess whether or not a bystander response can be induced in cultured human peripheral lymphocytes by vincristine, a chemotherapeutic mutagen acting as spindle poison, and by mitomycin-C, an alkylating agent already known to induce this response in human lymphoblastoid cells.

It is likely that a combination of pathways is involved in producing a bystander response.

A bystander response measured as increased yield of micronucleated cells was triggered in both MCF-7 and MDA-MB-231 cells.

More recently, irradiated haemopoietic stem cells were observed to produce a bystander response in vivo when these were transplanted back into animals (Watson et al, 2000).

Recently, we have found that irradiation through the cytoplasm of a cell has a similar probability of triggering a bystander response to that when the nucleus is directly irradiated [ 10, 25].

Accordingly, 12 h post 3 Gy irradiation was an ideal condition for the induction of a bystander response in HepG2 cells and hence was chosen as the representative point for the following mechanistic investigations.

Recent studies have shown that cytochrome- c (cyt- c) is also involved in the RIBE either as a sensor of bystander response (Yang et al, 2009) or as a signalling factor transmittable through gap junction (Peixoto et al, 2009).

These opposing activities may represent a self-limiting activation of ECM remodeling, which represents a novel potential bystander response.

Designing a modified ad hoc protocol for the cytokinesis blocked micronucleus (MN) assay, we detected the presence of a dose-dependent bystander response in untreated cultures receiving the conditioned medium (CM) from mitomycin-C (MMC) or vincristine (VCR) treated cultures.

The results suggest that energy/REDOX metabolism may be involved in the expression of a radiation induced bystander response.

In this study we show direct evidence for the production of a radiation-induced bystander response in primary human fibroblasts.