Exact(6)
Recently, luminescent conjugated oligo- and polythiophenes (LCOs and LCPs) were introduced as a novel class of amyloid-imaging ligands with the ability to identify and differentiate a broader subset of protein aggregates compared to conventional dyes.
Luminescent conjugated oligothiophenes (LCOs) have proven useful for optical identification of a broader subset of disease-associated protein aggregates than conventional ligands, such as thioflavin T and Congo red.
Characterization of Aβ plaques and neurofibrillary tangles in brain tissue sections: Previous studies have shown that pentameric and heptameric LCOs identify a broader subset of Aβ deposits in brain tissue sections than conventional amyloid ligands.
Alloreactive cells were enumerated because they are likely to be selected on a broader range of self-pMHC and represent a broader subset of the CD4+ T-cell compartment (Felix and Allen, 2007; Chu et al., 2009).
The major advantages of thiophene-based probes over conventional amyloid ligands, such as Congo red, thioflavin T (ThT) and their derivatives, are their ability to identify a broader subset of disease-associated protein aggregates and their utilization for spectroscopic assignment of heterogeneous populations of deposits or distinct protein aggregates.
Overall, we have demonstrated that a combination of fluorescent ligands will facilitate the detection of a broader subset of amyloid topologies, and the results presented also underline the importance of understanding the variety of disease-associated protein aggregates that are identified with distinct ligands.
Similar(54)
The purpose of this study was to report the complete sequences for a broad subset of validated Alu insertions from the Pilot 1000 Genomes Project.
To determine a broad subset of genes whose transcription is influenced by SL-1, we further expanded the analysis of our microarray data to include all of the statistically significant (p < 0.02) genes that are transcriptionally regulated (i.e., genes induced and repressed) by SL-1 and SL-A.
A previous study (Jakobsson et al. 2008) genotyped some 500,000 SNPs in a broad subset of 485 participants from the HGDP CEPH and included 25 Native American participants (7 Piapaco from Colombia: geographic coordinates 3°N, 68°W; 10 Maya from Mexico: 19°N, 91°W; and 8 Pima from Mexico: 29°N, 108°W) who represent Native Americans in this study.
In addition to the potential for government funding or public-private partnerships, foundations may be able to partner with each other to fund such grants, which could take into account a broad subset of chronic diseases treated at academic medical centers.
Human resources is a profession with a broad subset of areas, from compensation and benefits to recruiting to labor relations.
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