With the prevalence of heterotypic cell-in-cell structure formation between virus-loaded immune cells and tissue cells during chronic infection, in-cell infection of non-susceptible ECs with broader potency and higher efficiency might be more inclined to form the viral latency.
In a preliminary screening for its antimicrobial potential, it showed a broad spectrum potency, in line with previous studies on medicinal plants (Omoregie and Folashad 2013; Silva junior et al. 2009; Zampini et al. 2009).
As a point of comparison, bNAbs against HIV-1 gp120 and influenza HA target conserved regions, and in these cases a compact structural epitope that focuses on conserved residues is likely critical for broad potency.
Since the V3 loops vary in positive charge between X4 and R5 HIV-1 strains, it is likely that the broad potency observed for SPL7013 and SPL7115 is due in part to interactions with conserved clusters of positive charge on gp120.
Recent identification of artemisinin-tolerant parasites in southeast Asia, however, has raised concerns that the broad potency of ACTs against all parasite strains may be waning, which could lead to a resurgence in malaria deaths (Dondorp et al., 2009; Ariey et al., 2014).
Additionally, bisphosphonates have been shown to have a broad anti-tumoral potency (anti-migration, anti-angiogenic and immunostimulation), at least in vitro.
The assays were required to demonstrate a Z′ score of ≥0.5 and to have a test retest reliability with an r of ≥0.75 for the 20 SGSM compounds representing a broad range of potencies (IC50 values for inhibiting the production of Aβ42 ranging from ∼1.3 μM to 30 nM).
This may have a broader applicability as a general concept for increasing the potency of long-peptide or protein vaccines.
Thus, the high potency of BiTE molecule may derive from a broader spectrum and a greater number of effector T cells engaged to kill target cells.
Current opinion in critical care favours the early use of antibiotics, guided by local pathogen surveillance, usually of a broad spectrum and high potency, that is equally applicable to all clinical settings in patients with suspected severe sepsis [ 1].
