Sentence examples for a broader efficacy from inspiring English sources

It is reasonable to expect that inhibitors of multiple kinases possess a broader efficacy than a single-targeted inhibitor.

On the other hand, multi-targeted kinase inhibitors, or a combination of inhibitors, may target additional angiogenic pathways and may carry out a broader efficacy and may avoid resistance.

Although BCA (Fig. 1E, left) and SDG (Fig. 1E, right) were both effective in reducing GL261 cell growth from 50  μmol/L onward, BCA showed a broader efficacy in all other tested glioma cell lines.

The other two available vaccines are based on PS conjugated to carrier proteins to enhance the immunologic response, with a broader efficacy in infants and young children, despite the poor protection against less common serotypes.

One possible reason for dual PI3K/mTOR inhibitors inducing more radiosensitivity could be that dual PI3K/mTOR inhibitors have a broader efficacy across more genotypes with pro-apoptotic effects identified in a wider range of cell lineages compared with agents targeting only one component of the pathway.

Therefore, vabicaserin offers the possibility of a new antipsychotic medication with broader efficacy (e.g., cognitive symptoms) as well as improved safety and tolerability over existing antipsychotic agents.

We know CAM is widely utilised yet we acknowledge here that the broader efficacy and safety of individual CAM modalities are often ambiguous [ 17, 18].

Current biologic agents have not been able to break the ceiling in terms of delivering better and broader efficacy for treatment of autoimmune diseases.

With this carefully validated diagnostic kit, sample sizes including that of MCI and other dementia subtypes, to determine the broader efficacy of this platelet array, can be increased in the future.

Given that these hypotheses were concerned with mechanisms by which the interventions may or may not have led to change rather than broader efficacy questions, we used the per-protocol sample for these analyses unless otherwise specified.

Elucidation of the biosynthetic pathway to pneumocandins is the first step in applying pathway manipulation and biocombinatorial chemistry approaches to engineer new derivatives with broader spectra of activity and improved physiochemical characteristics to meet the challenges of broader efficacy and clinical resistance.