Exact(2)
Our results point to a broad suppression of invasive proteins after miR-10b inhibition, most likely through indirect mechanisms.
The transcriptional trends highlighted in this study imply that these cells become biofactories not by gain of function, but by a broad suppression of function to effectively push all of the cell's resources towards a very few important tasks such as the massive synthesis of lipids and of a large quantity of a minority of proteins.
Similar(58)
Mr. Johnson, the First Amendment lawyer, however, cited last year's Massachusetts case, Lorillard Tobacco v. Reilly, adding, "the governmental interest in protecting children from harmful materials does not justify an unnecessarily broad suppression of speech addressed to adults".
The fact that Sproutys exhibit such broad suppression activity, inhibiting a wide variety of angiogenic factors and cells, indicates that the suppression of Sproutys must enhance neovascularization.
Others have said the decision to prosecute Mr. Sadat — regardless of how outrageous his comments may have been — should be viewed as part of a broad political suppression in the country.
Hypercapnia and/or acidosis may modulate the interaction between host and bacterial pathogen via several mechanisms, resulting in a broad based suppression of the inflammatory response.
From the acute phase to the chronic phase, the immune response against the infection changes from the Th1-type to the Th2-type, and induces a significant increase of CD4+ CD25+ regulatory T cells, which have a broad immune suppression function [ 33].
While the broad suppression of search may be what policy makers intended, examining the distribution of teachers after the simulation, it is far from clear that bad schools benefit from this policy.
In addition, we also found broad suppression of genes involved in the senescence-related, mitochondrial/oxidative stress pathway in HK-derived iPS cells.
Importantly, the TREGS generated in this study were specific for the self-antigens included in the liposomes, emphasizing the goal stated earlier: inducing tolerance against specific self-antigens, without broad suppression of normal immune functions.
Conclusion: We find that ASH1 directly binds to the regulatory regions of alpha smooth muscle actin (αSMA), collagen I, tissue inhibitor of metalloproteinase-1 (TIMP1) and transforming growth factor beta1 (TGFβ1) in activated HSCs while depletion of ASH1 caused broad suppression of fibrogenic gene expression.
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