In summary, we demonstrate that CEN1 HC, a chemically synthesised 30 amino acid peptide sequentially derived from the previously described AMP centrocin 1, has a broad spectrum microbicidal effect, resistant to physiological salt concentration and serum containing wound fluid, combined with anti-inflammatory action.
The insecticides that target the VGSC have broad spectrum effects, as the structure of the VGSC is highly conserved across the animal kingdom, so there is a consequential detrimental impact on non-target species including pollinators and other beneficial's.
This effect was not PPARα-dependent in cell culture showing that lipistase has a broad spectrum of effects and is not merely a PPARα activator.
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, not only improves insulin resistance in patients with type II diabetes but also exerts a broad spectrum protective effects in variable animal models of neurologic or cardiovascular diseases.
MCDS allows to study a broad spectrum of effects determining creation of self-organized structures during the evaporation of solvent from the polymer solution (e.g. Rayleigh Bénard or Bénard Marangoni cells).
They exhibit a broad spectrum biological effects [10] with antibacterial [11, 12], antitumor [13, 14], anticonvulsant [15], anti-inflammatory [16], and antiviral properties [17].
The impact of androgens on salivary tissues is thus not limited to an influence on morphology [22] [24], but also includes a broad spectrum of effects on glandular physiology [25], [26].
Inflammatory blockade usually is accompanied by a broad spectrum of effects which promote neurogenesis, like reduction of cell death of new born neurons [14], attenuation of HPA axis activation [49], or the decrease in pro-inflammatory cytokines and serum glucocorticoid levels [15], [50].
RA has a broad spectrum of effects including biosynthesis of retinoids, phospholipids, and unsaturated fatty acids.
