Similar studies have yet to be conducted in other, more complex model organisms to test a broader relevance of these findings for human stress biology.
This knowledge has a broad relevance in general because of accumulation of toxic metals or developments of lacks of essential micronutrients throughout the food chain (idea of biofortification) and for phytoremediation or phytomining processes.
Additionally, progressive down-regulation of S100A16 as found in CRC, prostate and ovarian cancers (Additional file 3: Figure S2) demonstrates a broader relevance for S100A16 in the process of tumorigenesis of other human malignancies and warrants further investigation in these tumor types.
I have now modified the abstract, and several other passages in the manuscript to try to present a more tempered view of the possible broad relevance of the model of "speciation by budding".
The applications define the required product properties which cover both classical fields of process technology in the chemical industry as well as new emerging fields of electronics, energy and environmental technologies, life sciences, materials science and engineering, nanotechnology, and photonic technologies highlighting the broad relevance of mesoscale science.
We will continue striving both to publish the highest quality research on applied evolution, and to make the importance and broad relevance of evolutionary biology more accessible to all interested readers.
Smits and colleagues provide further evidence supporting the broad relevance of this locus to breast cancer by showing that the resistant congenic rats are also resistant to mammary carcinomas induced by an alternative carcinogen (N-nitroso-N-methylurea, or NMU) or HER2/neu overexpression.
It emphasizes the broader relevance of the study for understanding issues of governance and post-conflict development in Sri Lanka.
These explorations would allow students to explore the connections among them and the broader relevance of scientific advances to real-world issues.
The paper concludes by describing the broader relevance of this approach for other institutions and countries, and suggests it is something other university-, government- and industry-based research institutions could embark upon.
