In cytotoxicity assays, concentrations of PET-16 that inhibit the viability of a broad range of tumor cell lines have little effect on nontransformed cells, including normal human fibroblasts and primary human melanocytes.
In the present study, we have shown that ADPM01 and ADMP06 potently inhibit the viability of a broad range of cell types, with no apparent bias towards tumour cells of any particular tissue origin.
These include: whether suppressing c-FLIP in non-tumour cells compromises their viability; whether a broad range of breast cancer subtypes are affected by c-FLIP sensitization; and of particular clinical significance, whether the normally chemo-resistant CSC sub-populations within each of these heterogeneous subtypes are sensitive to de-repression of this apoptotic pathway.
We have recently shown in a study analysing TRD effects by FACS analysis in five cell lines identical with the current study (HT29, Chang Liver, HT1080, AsPC-1 and BxPC-3) that TRD inhibits cell viability over a broad range of concentrations (100 μM, 250 μM and 1000 μM) [ 26].
After 72 h viability decreased in response to a broad range of gefitinib or RAD001 concentrations in all treated cell lines.
Various cell viability assays in combination with a broad range of cell lines have shown that UCNPs with good surface treatment are nontoxic within a certain range of concentrations over a defined incubation time.
In order to rule out that the membrane permeability is induced by drug toxicity, the effects of VBRB on the cell viability of BRL cells were determined in a broad range of VBRB concentrations.
As we have shown, PFT-μ substantially inhibited cell viability already at low micromolar concentrations in a broad range of AML, T-ALL and B-precursor ALL cell lines (including BCR-ABL positive ALL).
Through their letters, Tycho and Kepler discussed a broad range of astronomical problems, dwelling on lunar phenomena and Copernican theory (particularly its theological viability).
In addition, a broad range of environmental and genetic insults can disrupt outer segment morphology to impair photoreceptor function and viability.
