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α1-Receptors are present in a broad range of structures including most motor, sensory, autonomic, and neuroendocrine-related areas (Acosta-Martinez et al, 1999; Day et al, 1997; Jones et al, 1985; Volgin et al, 2001; Williams and Morilak, 1997; Zilles et al, 1993).
These games range from groups of a few friends to 4,000-person organizations with a broad range of structures, goals and members.
Glycoside hydrolases (EC 3.2.1.-), comprise a ubiquitous and expanding super-family of sugar-releasing enzymes, which have a broad range of structures and substrate specificities.
Well-established tools for analysing functional connectivity in EEG or magnetoencephalographic studies are time frequency analyses of phase synchronization or analyses of generalized synchronization in order to detect coupled oscillators in a broad range of structures (Pikovsky et al., 2001).
It then iteratively (over 1000s of steps) searches through a broad range of structures generated from reordering these small bins for genome structures more likely to be true given the 3D data.
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With the aid of the BCPs, NPs can form a broader range of structures in the nanoscopically confined geometry.
Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts.
Optimally, and especially for protein kinases, a broad range of crystal structures should be obtained to characterize target flexibility, structure modulation via co-factor binding or posttranslational modification, ligand induced conformational changes, and off-target complex structures for selectivity optimization.
Synthetic small molecules like the kind C4 seeks to develop, which involve linking synthetic molecules together, should be able to bind with a broad range of biological structures, and have a long-lasting effect.
This automated webserver enables docking of small molecules with a broad range of Protein Structures available in the Protein Drug Target Database (PDTD) (http://www.dddc.ac.cn/pdtd/) [ 4].
This area has a population of 258,000 and encompasses a broad range of social structures, socio-economic status, education, availability of health-care services, neighbourhood dynamics, and levels of security [ 42].
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