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Reversible protein phosphorylation is implicated in the regulation of a broad range of cellular processes.
Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes.
Ubiquitination is a major player in regulating a broad range of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control [24], [25].
Although classically characterized as directors of cellular migration, chemokines have since have been shown to be involved in a broad range of cellular processes [15], [16], [19].
They are important cytoskeletal proteins involved in a broad range of cellular processes, from movement to cell division [61], [62], [63].
SigC is known to regulate the expression of at least 38 genes involved in a broad range of cellular processes and disruption of sigC resulted in a significant virulence attenuation in mice [31] and guinea pigs [32].
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Here, our in silico database together with biological validations suggests that AMPK is a master regulator of a broader range of cellular processes at more levels than previously recognized.
BRCA1 has been implicated in a remarkably broad range of cellular processes and has also been reported to interact with a large number of different proteins.
There is no a priori expectation that this class of regulatory ncRNA should be associated with regulation of a specific process, and our result likely reflects the broad range of cellular processes in which miRNAs are involved (and the large number of potential target mRNAs).
ERK1/2 is an important subfamily of MAPK that control a broad range of cellular activities and physiological processes.
These proteins are implicated in a broad range of cellular activities (Fig. 3A).
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