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All these data clearly support that the UCN3 gene plays an important role in regulation of adipocyte metabolism through a broad pathway.
From a mechanistic point of view, a broad pathway of fibril formation could be schematized by one of three straightforward models: i) the "refolding" model, in which self-propagating conformational rearrangements must occur in order to adopt a structure competent for self-assembly into fibrils.
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This is a very narrow definition as it does not take into consideration the location of the event or the function in a broader, pathway or network context.
These pathways include those identified in the canonical pathway analysis (cell cycle regulation, apoptosis, and LPS-stimulated MAP kinase signaling) as well as the nuclear factor kappa B (NF-κB) signaling pathway and a broader pathway of endothelial barrier integrity that includes VEGF signaling.
Scattered across the broad pathway, men in suits talk into mobile phones.
Below, the broad pathway leading from the surrounding moat and entry gate to the base of the rock fortress passes through a wonderful water garden, about half of which has been restored by archaeologists.
Big red brick buildings accented by graceful cream-painted columns, a view of the Susquehanna Valley, wide lawns crisscrossed by broad pathways.
Remittances flowing from ILM's may affect child nutrition through two broad pathways.
The GRAIL genes were mapped into two broad pathways: glycolysis and inhibins/activins.
Excluding seven broad pathways, between 1 20 metabolites fell into 73 more specific KEGG pathways (Additional file 4).
This broad pathway-based approach to understanding the similarities in, and differences between, animal models and human diseases may have broader utility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com