The fact that PTGDS and SASH1 expression remained associated with carotid plaques after adjustment on smoking status may indicate a broader implication of these genes in atherosclerosis than the sole effect induced by smoking.
NHase is an enzyme with a function unrelated to microcin production and, thus, a broader implication of our findings is that a small protein cannot be automatically excluded from classification as a precursor to a natural product, even if it is homologous to a protein with a known function.
The other broad implication of our interpretation is that interventions should operate at multiple levels.
A broader implication is that release of the C subunit from anchored PKA holoenyzmes may not be required for the phosphorylation of nearby substrates.
"A relief operation can begin by gathering the expert humanitarian actors who know the broad implications of a situation into a single room," she continued.
Herein, we explore how Cisco Systems addressed these two challenges followed by a discussion of the broad implications of adopting the agile development method.
As variations in biosynthetic gene content are expected to correlate with variations in the small-molecule producing capabilities of a microbiome, the broader implication of these observations from a drug discovery perspective is that the dominant biosynthetic systems of geographically distinct soil microbiomes are expected to encode orthogonal, largely unexplored collections of natural products.
A conceptual framework illustrating the broad implications of patent protection is illustrated in Figure 1.
However, research on mobility-related social exclusion is often characterized by the lack of clear conceptualizations (Lucas et al. 2016b) as well as by a tendency to overlook "the broader implication of a comprehensive transport policy" (Beyazit 2011, p. 130), so that its influence on planning practice is quite limited.
