The phrase "a broad function in" is correct and usable in written English.
It can be used to describe a wide-ranging role or responsibility within a specific context or field.
Example: "The software serves a broad function in enhancing user experience across various platforms."
Alternatives: "a wide role in" or "a general function in".
Hence, association with these four Rab proteins suggests that C9ORF72 may have a broad function in facilitating endocytic trafficking events.
It has a broad function in cellular processes like plasma membrane fusion, pheromone signaling or protein sorting [ 24- 26].
Second, do Siglec family members directly interact with other families of pattern recognition receptors and play a broad function in regulating innate immunity?
In accordance with its expression pattern, BRI1 exerts a broad function in cell elongation and differentiation, which includes the differentiation of vascular tissue.
Although the mode of action shared similarities, Kaiso did not associate with the p120-REST-CoREST complex, suggesting that nuclear p120 might have a broad function in the regulation of transcriptional repression.
Pkh-kinase regulation of endocytosis could thus potentially be used to selectively adjust the composition of the plasma membrane, suggesting that sphingolipid signaling might have a broad function in organizing the plasma membrane.
Other hematopoietic cell types, such as platelets [ 64], eosinophils [ 65], and hematopoietic progenitors [ 66], also participate in angiogenic processes, but it remains to be established whether they can directly promote tumor angiogenesis, rather than having a broader function in supporting tissue inflammation and remodelling.
Deletion of Sirt3 resulted in a marked elevation of acetylation of several mitochondrial proteins (Lombard et al, 2007), suggesting the presence of many substrates of SIRT3 in mitochondria and a broad function of SIRT3 in metabolic regulation.
The widespread consequences of mutations in GNA1 indicate a broad function of this Gα subunit in appropriation of intracellular resources to environmental (especially nutritional) conditions.
Previous studies indicated that the MTA proteins form exclusive alternative NURD complexes and have broad function in transcriptional regulation [ 28, 29].
This suggested a broader function for PAP in nucleotide metabolism and has implications in inflammatory pain conditions where extracellular pH is reduced.
