The findings that were presented showed that these protocols might be valuable for covering a broader fraction of the phosphoproteomic spectrum.
Therefore, dedicated efforts are still needed to identify prognostic biomarkers expressed in a broader fraction of breast cancer patients that would transcend the categories of ER/PR+, HER2+ and triple negative, and be informative of disease outcome.
Since the binding activity was detected in a broad range of fractions and only very little materials were eluted after fraction 68, the GWE, with the typical HPLC profile shown in Figure 3B, was used in all following experiments without further fractionation.
Peptides with one phosphate group plus one or more additional basic residue elute in a broad range of fractions to the end of the SCX gradient, with no discernible relationship between phosphate site and fraction of elution.
A broad spatial distribution of the fraction of bound IFNAR arises due to the spatio-temporal distribution of secreted IFN-β, and is enhanced by early autocrine effects.
Dnm1 elutes over a broad range (fractions 4 12) with the majority of signal between 440 and 669 kDa compatible with an oligomeric complex (Fig. 4D).
Laser-induced incandescence images of soot volume concentration, at the center of the fire plume and at a height within the active flaming region, reveal the appearance of large-scale particle-like features across a broad range of apparent volume fraction, which emit at an intensity that is comparable with that of the laser-heated soot particles.
Simultaneous elimination of DNA damage-induced defense mechanisms, through transient pharmacologic inhibition of PP2A, is proposed as a new method for enhancing the efficacy of non-specific cancer chemotherapy regimens against a broad spectrum of low growth fraction tumors, such as PHEOs, that are commonly resistant to cytotoxic drugs.
Monday's equities market seemed to set the tone for the week by edging slightly higher, when the broader index gained a fraction of a point, as the Fed meeting and the Senate vote on extending the Bush tax cuts held traders at bay.
Conformation of polymer chains strongly confined in a narrow channel space was studied over a broad range of polymer volume fractions φ using lattice Monte Carlo simulations.
