The phrase "a broad effect of" is correct and usable in written English.
It can be used when discussing the wide-ranging impact or influence of something on a particular subject or area.
Example: "The new policy has a broad effect of improving employee morale across the organization."
Alternatives: "a wide impact of" or "a significant influence of".
This will have a broad effect of putting Republicans on the defensive against the "Party of No" label (which they're already worried about).
A broad effect of Hsp70 on the regulation of other Hsps is consistent with previous research, but the positive direction of the effect is unexpected.
Moreover, a number of associated biological processes were unveiled, including cell cycle, growth, apoptosis, transport, immune system and cell adhesion, highlighting a broad effect of both doxorubicin and etoposide on cell fate (Fig. 4a).
Using global approaches, we identified an increase in CpG island and histone methylation upon folate depletion despite unchanged levels of total 5-methylcytosine, indicating a broad effect of folate depletion on epigenetic regulation.
Taken together, these observations pointed to a broad effect of oral tolerization on bone marrow, affecting neutrophils as well as eosinophils, and prompted further examination of granulopoiesis in vivo and ex vivo in the same strain originally used (BP-2).
Our microarray data are consistent with a broad effect of HNF4α on liver functions, and more importantly, the microarray analysis provides a genomic view for the role of HNF4α in the inflammation response, which greatly extends the observations from both animal- and cell culture-injury models.
They can have a broad effect on every aspect of physiology, including embryogenesis, metabolism, and growth and development.
Our data suggest that TKR surgery has a broad effect on the functional impact of knee osteoarthritis in the community.
Moreover, the same sample showed, within the 3rd peak, a smaller amount of polymers with Mw > 50 kDa indicating a broader effect of phosphatidylcholine on the distribution of high and low molecular weight HA polymers.
This finding suggests a broader effect of the SPX domain on phosphate metabolism because Ptot and poly P levels are cumulative measures that result from the integration of uptake, allocation, storage and efflux of phosphate over time.
Moreover, the direction of other cytokine responses observed in this study (for example, IFNγ) seems consistent with the stress literature and tentatively suggests a broader effect of stress management training on immune function, but larger studies are needed to validate this effect.
