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These methods allow researchers to regulate protein activity with exquisite spatiotemporal control, and open up new possibilities for studying the roles of proteins in a broad array of cellular processes and biological functions.
Using this significance threshold, 127 proteins (82 up-regulated, 45 down-regulated) representing a broad array of cellular functions showed changes in abundance.
Collectively, PP2A holoenzymes target a broad array of cellular phosphoproteins.
DCHF-DA was used to assess the presence of a broad array of cellular ROS levels, as previously described.
More than 2 decades of work have yet to conclusively determine the physiological role of the synuclein proteins, even though these abundant brain constituents are participants in a broad array of cellular processes.
The human NR4 subfamily includes nerve growth factor I-B (NGFI-B), nuclear receptor related 1 protein (NURR1), neuron derived orphan receptor 1 (NOR1), and is involved in a broad array of cellular metabolic processes; vascular remodelling and cancer [ 99, 100].
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Recent evidence has shown that in Saccharomyces cerevisiae HSF directly activates the expression of genes whose protein products are involved in protein folding and degradation, ion transport, signal transduction, energy generation, carbohydrate metabolism, vesicular transport, cytoskeleton formation, and a broad array of other cellular functions (Hahn et al. 2004).
Even more remarkable is the broad array of cellular networks that intramembrane proteases have come to regulate.
These interactions, together with other proteins that bind to HPV16, alter a broad array of cell cycle progression; for example, they block cellular proliferation by causing cell cycle arrest in S-phase [ 12, 50, 51].
A smartphone is a cellular telephone with an integrated computer that is capable of performing a broad array of tasks, including running various downloadable applications (apps) that typically are not associated with a cellular phone.
DOI: http://dx.doi.org/10.7554/eLife.05996.002 A relatively small number of highly conserved cellular signaling pathways are responsible for a broad array of distinct, specific biological processes in metazoan development.
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