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The phrase "a breakthrough in the" is correct and usable in written English.
It can be used when discussing significant advancements or discoveries in a particular field or subject.
Example: "The researchers announced a breakthrough in the treatment of Alzheimer's disease, offering new hope to patients and their families."
Alternatives: "an advancement in the" or "a significant development in the".
Exact(60)
A breakthrough in the talks in Ukraine?
What would be a breakthrough in the field?
"This is a breakthrough in the magnetic world".
But Juventus found a breakthrough in the 80th minute.
Tucker believed the plan was "a breakthrough in the art".
Will 2016 herald a breakthrough in the housing crisis?
A breakthrough in the conventional sense may never come.
In other words, it's a breakthrough in the whole area of chemotherapy.
Especially after Monday's events, there's no chance of creating a breakthrough in the Arab-Israeli dispute.
Ms. Hynes said the new school signified a breakthrough in the arts in Ireland.
Despite past problems, the cease-fire today was a breakthrough in the talks.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com