A bona fide feeding frenzy takes place over sardines.
In order to validate miR5640 as a bona fide miRNA, we confirmed its expression and expression of its precursor in roots using RT-qPCR.
Nevertheless, these experiments show that a bona fide promoter driving the expression of ncRNA is present in the region ∼300 400 bp upstream of the mRNA transcription start site.
In the present work, we further characterised RS5 as a bona fide RS by heterologous expression and functional identification in E. coli.
Next, we tested whether the expression of a bona fide Wnt/β-catenin transcriptional target, such as lef1, was increased upon loss of Amotl2a activity.
We infer from these data that LRH-1 is a bona fide target whose inhibition would selectively block aromatase expression in breast, while sparing other sites of expression.
SMARCA2, the other ATPase subunit of the SWI/SNF complex, is also a bona fide tumor suppressor with frequent loss of expression via epigenetic silencing and more recently, mutational inactivation (Oike et al., 2013).
NKX3.1 is a bona fide tumor suppressor gene with prostate-restricted expression [ 14].
Despite the validation of LIMD1 as a bona fide TSG, the processes controlling LIMD1 gene expression remain to be fully elucidated.
STAT3, a bona fide TCPTP substrate [ 26, 29], regulates the expression of genes involved in inflammatory reactions induced in response to tissue injury and infection [ 66].
Therefore, based on sequence identity, sequence alignment and gene expression pattern, we concluded that PiSSK1 is a bona fide SSK1 gene.
