4-AP is traditionally used as a blocker of A-type potassium channels [24], [29].
Epileptiform-like discharges were induced by 50 500 μM 4-aminopyridine (4-AP, Sigma-Aldrich), a blocker of A-type potassium channels.
"This is not a monstrous carbuncle," she said of the Madison Avenue project, "but it is a blocker of the sun".
In addition, three investigational compounds having analgesic potential were examined: ZD-7288, a blocker of HCN channels; EAA-090, an NMDA antagonist; and WAY-132983, a muscarinic agonist.
Inhibitors of calcium channels and ionophores impair gravitaxis while caffeine, a blocker of the phosphodiesterase, enhances the precision of orientation.
Yamamoto et al., 1983 have shown that administration of α-tocopherol, a ROS scavenger and a blocker of lipid peroxidation improves the cellular health under ischemia [17].
To define the cytosolic components that link Podocalyxin to the cytoskeleton and regulate its activity as a blocker of adhesion, a number of groups have screened for intracellular Podocalyxin-binding proteins [13], [14], [15].
Using en bloc medullary preparations where the isolated RRG still functions in vitro and responds to CO2/pH changes, we show that a pre-treatment with fluoxetine, a blocker of the serotonin transporter (SERT) and 5-HT re-uptake, abolishes the RRG responses to CO2/pH.
The 4-aminopyridine is a blocker of the ion channel KCJN5, a potassium inwardly rectifying channel.
First proof of principal for this concept was derived from use of Fc OPG as a blocker of RANKL; a single injection of this protein in humans resulted in increased bone mass and rapid decline in bone resorption parameters [ 39].
We therefore tested the effect of cyclosporin A (Cys A), a blocker of the mitochondrial permeability transition pore (PTP) on CBD-induced cell death.
