Sentence examples for a biological progression from inspiring English sources

Are endoscopic ulcers a useful surrogate endpoint for a biological progression to clinical endpoints of ulcer complications (perforation, ulcers, and bleeds), hospital admission, or death?

Endoscopic ulcers may be an early step in a biological progression from mucosal injury to symptomatic ulcer and ulcer complication.

It is widely believed that there is a biological progression from lesser to more severe gastrointestinal damage with NSAIDs: from dyspepsia and other gastrointestinal symptoms, through endoscopic erosion and asymptomatic ulcers detected endoscopically, to ulcer complications (bleeding and perforation), and even to death [ 14, 15].

SPD may be best viewed as a novel tool for synthesizing biological hypotheses because it provides a likely biological progression underlying a microarray dataset and, perhaps more importantly, the candidate genes that regulate that progression.

The formation of atherosclerotic plaque is associated with a complex biological progression which includes the production of multiple biomarkers.

Preoperative plasma TGF- β levels are markedly elevated in men with prostate cancer metastasis and are a strong predictor of biological progression after surgery (Shariat et al, 2001).

Cells that have undergone EMT are able to transmigrate across basement membranes and stromal tissues as well as to intravasate into the circulatory system, which represents an important step in the biological progression of the malignant transformation of a tumor.

Biological progression was defined as an increase of 25% of any tumour marker and in case tumour markers had neither increase or decrease sufficiently to demonstrate biological progression or response, disease was biologically stable.

Therefore, determining biological response after chemotherapy provides important additional information, as patients whose metastases did not progress radiologically but who did demonstrate biological progression had similar prognosis compared with patients whose metastases showed radiological progression.

We present a novel computational approach, called Sample Progression Discovery (SPD), to discover patterns of biological progression underlying microarray gene expression data.

Qiu, P., Gentles, A.J. & Plevritis, S.K. Discovering biological progression underlying microarray samples.