The finding has shed light on a biological pathway that researchers now hope to turn into a therapy that slows the progression of Alzheimer's disease and other forms of dementia.
Immunological functioning might serve as a biological pathway underlying this association, since pro and anti-inflammatory cytokines are independent predictors of prognosis.
Background: The topology of a biological pathway provides clues as to how a pathway operates, but rationally using this topology information with observed gene expression data remains a challenge.
I have strategically deployed a variety of traditionally masculine tropes to convey I am competitive, competent and intent on empire building: I have referred to an adviser as the "Godfather" of a biological pathway, chided others for Monday morning quarterbacking and mastered more military jargon than reflects my personal tastes.
Furthermore, the Uniprot database16 (uniprot.org) showed that the co-expressed genes STR11, YLMG2, AT1G76405 all function in chloroplasts, which suggest the collapsing mechanism might contain a component of dysfunctional chloroplasts that is linked to a biological pathway related to our detected locus.
Sanofi and Regeneron say there are also preliminary signs dupilumab works against the skin condition atopic dermatitis, suggesting it can be blocking a biological pathway that contributes to multiple allergic conditions.
Our findings illuminate a biological pathway, namely moderation of amygdala-related anxiety, through which social support may confer resilience to psychopathology.
It also illustrates that pathway-centric clusters are able to capture similarity (or dissimilarity) of chemicals that target different proteins involved in a biological pathway.
for Set C, compounds were declared to be non-inactive against at least one target protein sequence involved in a biological pathway or biosystem that was stored in the NCBI's BioSystems database [35] (unique identifier: BSID).
"There are a number of factors that might influence achievement, but we were interested in whether there might be a biological pathway, and whether the brain development might explain the behavior differences".
A biological pathway is taken as a dynamic system.
