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It is likely that no more than one Hsc70 can occupy a binding position at each vertex.
In cases where binding domains were overlapping, if both positions were N sites, then the position was classified as non-binding, otherwise it was classified as a binding position.
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The incorporation of a fluorine in a TcR binding position has generated a peptide that elicits a better immune response than the native sequence, which was able to recognize and kill WT1+ cancer cells.
We suggest that this conformation may be required for correct transition of AR-C155858 from a transient binding position involving Asn and Arg to a more tightly bound position involving residues Lys, Asp, Leu and Ser.
Although AacC2c1 lacks a PAM-interacting domain, our analysis revealed that the PAM duplex has a similar binding position found in Cpf1.
May also said that, even though treaty change might not be achievable by the end of 2017 – the deadline Cameron has set himself for the referendum – the government did anticipate having "a legally binding position on these issues, so that people can have confidence in what they are looking at when they come to vote".
Here too, simulation with the R-enantiomer does not result in a different binding position.
The simulation we used, in which the inhibitor is placed in a predicted binding position at the start, would not be sensitive to this difference.
The docking predictions performed for ANTR1 indicated a distinct binding position for Pi and glutamate in the transportation cavity, at the level of Arg-120 and Arg-201, respectively.
The latter result was explained on the basis of elimination of hydrogen bonds between tyrosine-355 and other constriction site residues, giving 2-AG greater flexibility to attain an optimal binding position.
Since the smRNAs with a common 3' end binding position on the EST share the same predicted cleavage site we considered them as one group and categorized the targets according to the offset distribution of these smRNA groups (Table 4).
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