The phrase "a big setback in" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty encountered in a particular situation or process.
Example: "The project faced a big setback in the final stages due to unexpected technical issues."
Alternatives: "a major obstacle in" or "a significant hindrance in".
The decline would indicate that a large number of institutional investors fear that stocks could suffer a big setback in the coming six months.
The party suffered a big setback in the Scottish parliamentary elections, as they were pushed back into third place behind the Tories.
The Vancouver Opera suffered a big setback in 1988 when poor attendance at some of its arcane offerings, like works by Leos Janacek, caused the Briton Brian McMaster to quit as general director.
Lai's wish to enter broadcasting suffered a big setback in November when his attempt to buy Taiwan's China Times failed at the last minute.
He acknowledged his party had suffered a big setback in the European polls but said it had "stuck to its values" and was the only party putting the case for an internationalist UK in the EU.
In May, it suffered a big setback in China after the internet company Alibaba, in which Yahoo has a 43% stake, transferred one its key assets, Alipay, to a company controlled by its founder,Jack Ma.
"If it doesn't happen it will be a big setback for Brazil in terms of revenue, and a significant loss for the world in terms of new oil supplies".
Hooker is still a bit of a problem following the dumping of Dylan Hartley, and the recent defeat in a warm-up in Paris a big setback, but a place in the final is realistic.
The scrapping of the drug is a big setback for Bristol-Myers in the heated race to develop a combination of pills to treat hepatitis C, a viral infection that can cause liver scarring and liver cancer.
The loss in Kansas by Kris Kobach, a deeply conservative secretary of state and also a staunch ally of Mr. Trump, was also a big setback for the party in one of the most conservative regions in the country.
International rights groups condemned the move as a big setback for human rights in the country.
