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The phrase "a big question is" is correct and usable in written English.
It can be used when introducing a significant or important question that needs to be addressed or considered.
Example: "A big question is whether we can effectively combat climate change in the next decade."
Alternatives: "An important question is" or "A significant question is".
Exact(60)
A big question is whether they will.
A big question is identity.
"A big question is looming," he acknowledges.
"A big question is have Madrid got the money?
A big question is, which trees should we be planting?
A big question is, how much should one save?
A big question is how far up this might go.
A big question is: what is the Barclays' end game?
A big question is just how many problematic selectors had got through.
"A big question is what will happen to the 1.3 million forgone births?" Professor Johnson said.
But a big question is how best to do so and in whom.
More suggestions(17)
a big concerns is
a larger question is
a bigger question is
a big issue is the
a significant question is
a great question is
a large question is
a big issue is
a crucial question is
a pertinent question is
a first question is
a big chunk is
a common question is
a relevant question is
a key question is
a related question is
a central question is
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com