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The phrase "a big problem in" is correct and usable in written English.
It can be used to describe a significant issue or challenge within a specific context or area.
Example: "There is a big problem in the education system that needs to be addressed immediately."
Alternatives: "a major issue in" or "a significant challenge in".
Exact(60)
"Change is a big problem in Zimbabwe".
AIDS is a big problem in South Carolina.
This is a big problem in dentistry.
"It's a big problem in Thailand".
This is a big problem in Nepal.
Hygienic sanitation is a big problem in Africa's informal settlements.
Inflation is already a big problem in some emerging economies.
But this can become a big problem in his socialization.
It's a big problem in these older buildings".
Pain is a big problem in the N.F.L".
"Hypochondria is a big problem in this area".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com