Sentence examples for a big problem however from inspiring English sources

There is a big problem, however.

There is a big problem, however; the I.C.O.

There was a big problem, however.

There is a big problem, however: None of the experimental therapies and vaccines appears to be available in quantities large enough to treat the thousands in need.

A bigger problem, however, is the question of what should be considered standard give-and-take.

A bigger problem, however, is the uneven playing field separating the more seasoned cast members from Kate Turnbull as the Churches' daughter, Mags, a portraitist about to have her first New York solo show.

A bigger problem, however, lies in the evolution of both UN peace operations and the modern PMSC industry.

Perry's big problem, however, is that you rarely get a second chance to make a first impression.

The big problem, however, is not the unknown legal costs, but the exceedingly well-known exposure to real estate, both home mortgages and home-equity lines of credit.

The big problem, however, is that it's not just large foreign deposits that are taking a haircut; the haircut on small domestic deposits is a bit smaller, but still substantial.

The big problem, however, comes when you want to organize your videos: how do I tell iTunes that, say, my 10 favorite Arcade Fire performances are a related set?