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The phrase "a big problem for" is correct and usable in written English.
It can be used to describe a significant issue or challenge that affects someone or something.
Example: "The lack of funding is a big problem for the development of the new project."
Alternatives: "a major issue for" or "a significant challenge for".
Exact(58)
"That's a big problem for us".
"This is a big problem for legitimacy.
It is a big problem for Turkey".
That's a big problem for several reasons.
"It's a big problem for the country".
That's a big problem for starters.
It was a big problem for me.
Insomnia is a big problem, for example.
"It's a big problem for everyday life.
It's a big problem for the church.
This is a big problem for farmers.
More suggestions(17)
a big issue for
a considerable problem for
a formidable problem for
a substantial problem for
a sizeable problem for
a big trouble for
a bigger problem for
a greater problem for
a big time problem for
a larger problem for
a potential problem for
a big investment for
a big change for
a big miss for
a big help for
a big hurdle for
a big boost for
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com