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The brownD allele contains a big insertion of heterochromatin that drags not only the brownD allele, but also the wild-type brown allele to the chromocenter and thus performs silencing in trans (Csink and Henikoff 1996).
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Possibilities include either a "big bang" simultaneous insertion of a transposon and origin of V(D J recombination as proposed initially [1], [14], or a more gradual process [7].
And despite a big backcourt and the insertion of 6-foot-9-inch Kurt Thomas into the starting lineup the last nine games, that figure has fallen to 36 a game.
Therefore, the two direct interbase HBs between the dATP/dT base pair make a big difference with respect to efficient nucleotide insertion.
However, calling insertion and deletion (indel) variants still remained a big challenge none of the tools could achieve an average sensitivity higher than 33% or a positive predictive value (PPV) higher than 53%.
By then I had deposits of melanoma elsewhere too, in my right lung, under the skin on my right arm, a big one just below my liver, another pressing on my urethra, which had necessitated the insertion in 2011 of a plastic stent to keep my right kidney functioning.
A big, big game.
"A big, big fight.
And a big, big car.
(MoH1) …It was a big mistake, big, big mistake.
What a big difference.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com