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The phrase "a big exception to" is correct and usable in written English.
It can be used when indicating that something does not follow a general rule or pattern, highlighting a notable deviation.
Example: "While most students excel in mathematics, Sarah is a big exception to this trend, struggling with even the basics."
Alternatives: "a significant exception to" or "a notable exception to".
Exact(4)
This is a big exception to the way information has opened up over the past decade".
But in Russia, he is a big exception to the depressing rule that ruthlessness and sleaze, and not talent and hard work, are what count in business.
Though elite collegiate sports of the nominally amateur sort practiced in the United States are a big exception to the global rule, the N.C.A.A. tournament is not without company.
As Sherlock Holmes remarked of the curious incident of the dog at night ("The dog did nothing in the night-time...That was the curious incident"), events that do not happen can be as revealing as those that do.A big exception to the rule of declining political violence is the rise of terrorism.
Similar(56)
There is a single very big exception to this pattern and it is over the EU referendum.
There's another big exception to the general requirement that the defendant must have a criminal intent to be convicted.
Even the one big exception to this is instructive.
The big exception to this pattern is the attorney-general.
The big exception to this is the phenomenal Brian D. Coats.
There is one big exception to Trump's rightward tilt.
But Djokovic's loss in Paris was the big exception to the new rules.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com