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The phrase "a big exception is" is correct and usable in written English.
It can be used when introducing a notable deviation from a general rule or statement.
Example: "Most students passed the exam; however, a big exception is the case of those who did not attend the review sessions."
Alternatives: "a significant exception is" or "a notable exception is".
Exact(3)
A big exception is the United States, home to the other original research team.
A big exception is real estate investment trusts, which own rent-paying properties like office buildings.
A big exception is Alphabet/Google, which gets to play the ISP card because of its Fiber service.
Similar(57)
The other big exception is a work force in the emerging world.
Crime is down 5% year on year, violence in jails is down 25%, civilian fire deaths have fallen to the lowest level since 1919 all good news with an election due in November.The big exception is complaints about rats and mice, which rose 40%, to almost 32,000, in the year to March.
You mentioned in your review that ego is refreshingly absent from this show's vision of performance art; I'd submit that the big exception is "Playlist," a roughly hourlong installation featuring tracks from across Marclay's recorded career.
(The big exception is the Village Vanguard, which does it a few times a year).
(The big exception is Tennessee, which imposes up to a 16% tax on gifts above $13,000 a year to close relatives and above $3,000 to others).
The big exception is Exxon Mobil, whose chemicals business is now benefiting from speedy Asian growth.
The big exception is Native Americans, who live close to them and respect them.
The big exception is Venezuela, where inflation has risen to 27%.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com