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The phrase "a big drawback when" is correct and usable in written English.
It can be used to introduce a negative aspect or limitation associated with a particular situation or condition.
Example: "A big drawback when using this software is its steep learning curve."
Alternatives: "a significant disadvantage when" or "a major limitation when".
Exact(1)
The 1GB of memory is a big drawback when running Windows and Microsoft Office.
Similar(56)
ASBEST, Russia — This city of about 70,000 people on the eastern slopes of the Ural Mountains is a pleasant enough place to live except for one big drawback: when the wind picks up, clouds of carcinogenic dust blow through.
The biggest drawback when comparing with other delivery systems is the invasive nature of the operation.
When the job finally went to Abdullah, he arrived with a big drawback: since he had worked in a professional fight during the past six months, international rules prohibited him from being in the corner during Olympic bouts.
Millipede still suffers a big drawback of mechanical systems.
But they also have a big drawback: they are slow.
A big drawback is that there is no offline functionality.
A big drawback of controls may be political, an American consultant, James W. Castle, indicated.
For all its merits, however, the rule has a big drawback.
But seen from another angle this is also a big drawback.
One member of the I.O.C., Alex Gilady of Israel, called the lack of participation by major league players a big drawback.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com