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"a big difficulty in" is correct and usable in written English.
You can use it when referring to a large problem or obstacle related to a particular task or situation. For example, "I'm facing a big difficulty in finding a job."
Exact(4)
That reflects a big difficulty in e-government (and in writing about it): it touches on so many other things.
Almost all in-patients were admitted voluntarily.High drop-out rates are a big difficulty in treating crack patients.
When I'm in a time of need, when there's a big difficulty in my life, I'll sell it and I'll use the money".
"It was like a big difficulty in the beginning but by doing the tutorials, and my dad helping me, I actually learned it properly and got to know what I can do with this software," said Ritik in a phone interview about Tinkercad's drag and drop interface.
Similar(56)
The approach of the individual GPs differed, but very few were reported to have big difficulties in inter-personal relationships.
The biggest difficulty in putting a D-notice on a theatre production is that the script will often have a separate existence.
We believe the biggest difficulty in interpreting our work is the lack of a coherent and justified framework for the purpose, standards and remit of undergraduate dermatology education.
The biggest difficulty in Afghanistan, as in Iraq, remains the lack of an effective, accountable government.
The biggest difficulty in trying to predict Davis's second half is his career history.
The biggest difficulty in moving around Shinnecock Hills may be wading through the deep grass and gnarled undergrowth.
The biggest difficulty in human relations of all kinds is not to just create the condition of trust, but to hold that trust together.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com