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The phrase "a big difference to" is correct and usable in written English.
It can be used when discussing the impact or effect that something has on a situation or outcome.
Example: "The new policy made a big difference to employee morale and productivity."
Alternatives: "a significant impact on" or "a major change for".
Exact(59)
A big difference to whom?
That makes a big difference to us.
A big difference, to be sure.
It makes a big difference to me".
It was a big difference to Javi tonight".
Collectively, these things make a big difference to people's lives.
It is a big difference to have food".
"That made a big difference to us," Ms. Schmeling said.
But it made a big difference to my life.
It made a big difference to standby battery life.
"That's a big difference to our limited budget".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com