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The phrase "a big difference of" is not correct in standard written English.
It is typically used incorrectly; the correct form would be "a big difference in" or "a big difference between."
Example: "There is a big difference in the quality of service between the two restaurants."
Alternatives: "a significant difference in" or "a major difference between."
Exact(20)
These results demonstrate that there is a big difference of evolution conservation among different types of J-proteins, whish in in accordance with [ 44].
"And we have a big difference of opinion about what ought to be done".
Surely there is a big difference of voter psychology between schools and hospitals.
A big difference, of course, is that AT&T's reinvention experiment is largely over now while AOL's is just starting.
There is a big difference, of course, between being comfortable with the laws and using them aggressively.
And it's going to be a big difference of opinion between what he and I believe and what Vice President Gore believes.
Similar(37)
"We have a great opportunity to make a big difference on one of the biggest public policy issues internationally.
"It was spent throughout the community and made a big difference to all of us that Christmas".
The European commission said the "huge drop" in costs would make a big difference to millions of holidaymakers this summer.
"The Human Rights Act has made a big difference to the protection of rights in the UK.
That may not seem like a lot — but it will make a big difference to a lot of people.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com