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The phrase "a big difference is that" is correct and usable in written English.
It can be used to highlight a significant distinction between two or more subjects or ideas.
Example: "When comparing the two products, a big difference is that one is more energy-efficient than the other."
Alternatives: "a major distinction is that" or "a significant contrast is that".
Exact(12)
The needs of a language-teaching chatbot are rather different from other applications, and a big difference is that it's not only OK, but entirely necessary, for the chatbot to gently guide you through what you should say.
A big difference is that mice have researchers assessing their response to resveratrol, but we don't.
While the messages are similar, a big difference is that the newest book comes from Harvard.
A big difference is that with Asian elephants, only the males really have ivory.
A big difference is that a homoerotic content suppressed in Mr. Rauschenberg's assemblage is the primary content of Mr. Lee's.
A big difference is that he is again a co-director of Ballet Theater, this time with Jane Hermann.
Similar(48)
A bigger difference is that in 2013, Greece was desperate to avoid full nationalization for its banks.
A bigger difference is that Mr Miliband, much like his erstwhile hero President François Hollande of France, has not prepared his supporters for this tough reality.
A: The big difference is that a Drobo isn't just a backup system; it's a storage system.
We do know, however, that the one thing that seems to make a big difference is not on that list.
"It's a thing that has been an issue in the past, but one of the things that has made a really big difference is that [smartphones] are becoming very accessible.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com