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The phrase "a big difference from" is correct and usable in written English.
It can be used when comparing two things to highlight how they are not the same or how one is significantly different from the other.
Example: "There is a big difference from what I expected and the reality of the situation."
Alternatives: "a significant contrast to" or "a major distinction from".
Exact(60)
"It's a big difference from a year ago.
$15 a month for a pair of Dicks Cottons sunglasses seems like a big difference from your usual pricing?
"It was such a big difference from P1 to P2 and the car wasn't really that different.
"That's a big difference from last time".
There is a big difference from Jerusalem.
That's a big difference from last year".
"Twenty is a big difference from 25," he said.
That's quite a big difference from more conventional offsetting.
It's a big difference from the West Coast way of basketball".
That is a big difference from the main cause of corporate bankruptcies 10 years ago.
"There's a big difference from going home 8-6 or 9-5".
More suggestions(16)
a striking difference from
a marked difference from
a major difference from
a stark difference from
a big injection from
a huge difference from
a big step from
a big grin from
a significant difference from
a clear difference from
a threatening difference from
a big forehand from
a big mandate from
a sharp difference from
a big increase from
a palpable difference from
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com