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The phrase "a big change of" is correct and usable in written English.
It can be used when discussing a significant alteration or transformation in a situation, process, or condition.
Example: "The company is undergoing a big change of strategy to adapt to the new market demands."
Alternatives: "a major shift in" or "a significant alteration of".
Exact(26)
It turned out to be a big change of possession and ended with a score".
He does not see this as a big change of heart.
For our top judges, it has involved a big change, of practice and of culture.
"My change of dress is also a big change of pace".
Unlike many Lithuanian politicians, he is a good administrator.To the disappointment of some left-wingers, he shows no sign of bringing a big change of policy.
But given the perversity factor in fashion, now is exactly the moment for designers to have a big change of heart.
Similar(33)
There have been many reports of relatively minor changes to components of an experiment producing a big change on the metabolome of an organism.
We can see that there is a big changes of p.d.f.f
5. Amazon made a big change to some of its guidelines.
They wrote in the blog post: "Change is scary, and this is a big change for all of us.
It was a big change for both of us".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com