The phrase "a big challenge the" is not correct and usable in written English.
It appears to be an incomplete phrase and lacks proper context or structure to convey a clear meaning.
Example: "A big challenge the team faced was meeting the project deadline."
Alternatives: "a significant challenge" or "a major obstacle".
Therefore, it remains a big challenge the development of new and effective drugs to defeat cancer.
Clow, global director of media arts at New York-based ad agency TBWA/Worldwide, told the Cannes Lions International Festival of Creativity: "It's now a big challenge, the marketing and communications for Apple.
Army recruitment is a "big challenge" the defence secretary has said, as the Army launched a £3m campaign to boost regular and reserve forces.
"We're looking at six wins out of seven to confirm a place in the playoffs," Hessenthaler told BBC Radio Kent.: "That's the challenge and it's a big challenge," the 46-year-old continued.
There's been a lot of excitement around the possibilities that smartphones and especially tablets offer to traditional publishers, but they also present a big challenge — the costs are often too high, said MediaWire CEO Clifford Hoffer.
A big challenge the startup is going to face is that people are required to tag all their existing items in Outlook manually, which is bound to take a lot of time for those who use Outlook a lot (i.e. Taglocity's core audience).
Although most would argue that software patents pose a bigger challenge, the U.S. Supreme Court has recently focused on biomedical patents.
A big challenge in the present study was the aging of the participants.
How to choose critical gene from hundreds of DEGs is a big challenge for the researchers to continue the subsequent experiments after the chip experiment is finished.
That will, or would, be a big challenge to the culture and the sovereign will of Treasury ministers and mandarins.
We felt that it would be a big challenge for the university to protect the students".
